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Meta-analyses of berberine trials show modest reductions in hemoglobin A1c (approximately 0.5-0.7%) and fasting glucose, with variable effects on body weight, though many studies have methodological limitations and high heterogeneity
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, 172 , 3929-3943, doi: Zheng, W., Zhou, C
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When administered following an initial 12-week intensive lifestyle intervention, TZP increased the WL (105)
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